We have tried both but nowhere close to the dosages used in the studies. We have PharmaNAC but our son doesn't like the fizziness in that drink (it tastes great). Hopefully can try it again once he is older and starts liking fizzy drinks. We didn't try liposomal form of glutathione but did try transdermal glutathione. Thought we see very slight improvement at high dose but no major wows. Neither glutathione or NAC can work within cells (intracellularly) or cross blood brain barrier, so may just be acting as source of cysteine. There is a published study that showed directly supplementing glutathione (GSH) didn't raise intracellular GSH levels but did raise cysteine levels. What works best us to raise intracellular GSH which has been shown in studies is MB12 shot with methyl folate. That was a wow. Other way is using antioxidants such as ALA and vitamin C.

Oral absorption of MB12 is only 5%, so not very effective. There are MB12 lollipops but need to keep do that every couple of hours which is not practical. There is MB12 nasal spray as well but that is more cumbersome than the shots and not as effective. Need to make sure it is methyl B12, not other forms as that is what is found deficient in ASD, not B12 in general. Too much B12 can cause folate issues, so at some point need to add folate/folinic acid or methyl folate as well to maximize intracellular GSH (i.e. Jill James study)

On yeast, high dose NAC didn't cause much yeast issue for us (PharmaNAC), but even a small amount of ALA (which is dithiol sulphur compound) caused yeast issues. There are not many studies on yeast in autism though it is very common. There are a few case studies published in journals and there is some data published by Dr. Shaw but not in journal.

Our biomed dr. has found the mB12 injections more effective in his patients but sometimes they cause too many side effects. Some of those who can't tolerate the injections are able to tolerate the sublingual mB12. But his preference is definitely for trying the shots first.

@A MyAutismTeam Member - interesting. I have not found that in the literature.

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A MyAutis...

thank you! much appreciated. What are your thoughts on oral B12? Studies seem to show that oral B12 in high enough doses is as good as a b12 shot. Thoughts?